If you’ve worked in drug development, whether it be at a biotech or pharma company, you know just how critical Good Laboratory Practice (GLP) toxicology studies are in the preclinical process. These studies help evaluate the safety and potential risks associated with...
Preclinical studies are essential for advancing oncology drug development programs. They provide valuable insights into a drug candidate's safety and efficacy before it moves into clinical trials. A well-designed preclinical study can increase the likelihood of...
Sykesville, Maryland - June 20, 2023 Noble Life Sciences, a leading contract research organization in Maryland, is proud to announce that it has received renewed accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)...
Introduction Humanized mice are exceptional models for preclinical testing of cell and gene therapies. Standard mouse models can provide an approximation of human systems, but the murine immune system has important differences from humans. To overcome these...
Introduction A patient-derived colon cancer Xenograft (PDX) model has been established for the first time by Noble Life Sciences by implanting cryopreserved PDX fragments into a transplant compliant mouse host. PDX models have advantages over cancer cell line...
Introduction With the increasing incidence of patients worldwide diagnosed with cancer, the development of effective, safe, and economically viable anticancer therapeutics remains a high priority. Early anticancer drug discovery and development is very challenging...
Safety pharmacology and toxicology studies are performed to understand the onset, degree of severity, and time length up to which a particular dose of a new drug demonstrates any toxic effects. The dosing regimens for such studies usually range from acute studies...
- Preclinical toxicology is a critical component of the drug development process. The goal of toxicology testing is to support the transition of a new drug candidate to patients in Phase I clinical studies through an investigational new drug (IND) filing. The IND...
Noble Life Sciences now offers Digital PCR services and expands Molecular Biology Facility’s capability for cell and gene therapy applications. Our digital PCR services utilizes the Qiagen QIAcuity four-plate digital PCR (dPCR) instrument that detects up to 5...
Cell and gene therapies have the potential to change the way rare diseases are treated, offering novel and more effective treatments for patients with limited options. This article explores the various options available from the government to help rare disease drug...