Introduction Humanized mice are exceptional models for preclinical testing of cell and gene therapies. Standard mouse models can provide an approximation of human systems, but the murine immune system has important differences from humans. To overcome these...
Introduction The study aims to establish an orthotopic liver cancer model in nude mice and evaluate the anti-tumor efficacy of Sorafenib. Liver cancer is a leading cause of cancer deaths worldwide, accounting for approximately 830,000 deaths each year. Hepatocellular...
Sandeep Dhalla, Turhan Coksayganb, Tyler Hoffmana, Matthew Moormana, Anne Lercha, Jin-Qiang Kuanga, Malathi Sathyamoorthya, Alla Danilkovitcha, Osiris Therapeutics, Inc., 7015 Albert Einstein Dr, Columbia, MD, 21046, USA, and University of Maryland, 655 W. Baltimore...
Service Description The rabbit abdominal sidewall adhesion model is a reproducible and effective model to study adhesion formation and evaluate materials to prevent adhesions. Moreover, the model is flexible, e.g., laparoscopic procedures can be employed and various...
Introduction Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery. The...
Introduction Skin serves as a barrier between the external environment and the underlying tissues. When the integrity of the skin is disrupted this barrier is compromised. In order to prevent further damage or infection, proper wound healing should occur immediately....
Introduction Type 1 diabetes is an autoimmune disorder that affects nearly 347 million people worldwide. The autoimmune disorder is characterized by the destruction of insulin-producing beta cells in the pancreas by the patient’s immune system. Because insulin...
Introduction The immune system is extraordinarily effective at eliminating small, local infections. However, when infection occurs systemically, such as in bacterial septicemia, a cascade of events is initiated in which potent mediators released by the immune system...
Introduction Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test...
Introduction Noble Life Sciences, in partnership with IBT Bioservices, has optimized a cotton rat RSV model and successfully demonstrated its use to test the efficacy of a therapeutic agent against RSV. RSV is a major human pathogen causing mild to severe respiratory...