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Colon Cancer PDX Model:  Platform for Preclinical Drug Screening
Colon Cancer PDX Model: Platform for Preclinical Drug Screening

Introduction A patient-derived colon cancer Xenograft (PDX) model has been established for the first time by Noble Life Sciences by implanting cryopreserved PDX fragments into a transplant compliant mouse host. PDX models have advantages over cancer cell line...

Toxicology Study Design Considerations
Toxicology Study Design Considerations

Safety pharmacology and toxicology studies are performed to understand the onset, degree of severity, and time length up to which a particular dose of a new drug demonstrates any toxic effects. The dosing regimens for such studies usually range from acute studies...

New Digital PCR Service Now Available
New Digital PCR Service Now Available

Noble Life Sciences now offers Digital PCR services and expands Molecular Biology Facility’s capability for cell and gene therapy applications. Our digital PCR services utilizes the Qiagen QIAcuity four-plate digital PCR (dPCR) instrument that detects up to 5...

GLP Custom Polyclonal Antibodies
GLP Custom Polyclonal Antibodies

For over 30 years, Noble Life Sciences has supplied custom polyclonal antibody services using a variety of animal species. Our GLP custom polyclonal antibodies are ideal for vaccine potency testing. We offer two standard protocols which are designed to maximize...

Medical Device Testing Services
Medical Device Testing Services

Noble Life Sciences offers a wide range of testing GLP services to ensure both the efficacy and safety of medical devices with significant expertise in orthopaedic, cardiovascular, trauma, and wound models. We provide surgical expertise and support utilizing state of...

TCGA Publishes Highly Anticipated Results on Tumor Sequencing
TCGA Publishes Highly Anticipated Results on Tumor Sequencing

The Cancer Genome Atlas (TCGA)—a comprehensive and coordinated effort to accelerate understanding of the molecular basis of cancer through the application of genome analysis technologies, supported by the National Cancer Institute and National Human Genome Research...

Antibiotic Resistance- Challenges and New Opportunities
Antibiotic Resistance- Challenges and New Opportunities

The misuse of existing antibiotics in clinical practice and the introduction of antibiotics into the environment in combination with the inherent adaptive nature of microorganisms has led to a major global health crisis with the evolution of antibiotic-resistant...

Orthotopic Liver Cancer Model Established in Athymic Nude Mice
Orthotopic Liver Cancer Model Established in Athymic Nude Mice

Introduction The study aims to establish an orthotopic liver cancer model in nude mice and evaluate the anti-tumor efficacy of Sorafenib. Liver cancer is a leading cause of cancer deaths worldwide, accounting for approximately 830,000 deaths each year. Hepatocellular...

Anti-Infectious Therapeutic Development Services
Anti-Infectious Therapeutic Development Services

WHY NOBLE LIFE SCIENCES? • Dedicated Study Director for each project• Highly Skilled Technical Team• Qualified animal Care Team• Interactive Study Design and ExecutionNoble’s highly experienced scientist have been implementing effective and efficient approaches to...

Oncology Drug Testing
Oncology Drug Testing

WHY NOBLE LIFE SCIENCES? Dedicated Study Director for each project Highly Skilled Technical Team Qualified animal Care Team Interactive Study Design and Execution Noble’s highly experienced scientist have been implementing effective and efficient approaches to help...

GLP Toxicology Services
GLP Toxicology Services

Toxicology studies are required to determine the adverse effects of drug candidates and the effect of dosage on toxicity. With extensive experience in vaccine and drug development, Noble Life Sciences’ staff is dedicated to helping you complete your project in a...

Rabbit Abdominal Sidewall Adhesion Model
Rabbit Abdominal Sidewall Adhesion Model

Service Description The rabbit abdominal sidewall adhesion model is a reproducible and effective model to study adhesion formation and evaluate materials to prevent adhesions. Moreover, the model is flexible, e.g., laparoscopic procedures can be employed and various...

Continuous Drug Infusion Model with an Implantable Osmotic Pump
Continuous Drug Infusion Model with an Implantable Osmotic Pump

Introduction Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery. The...

Streptozotocin Induced Diabetic Rat Model
Streptozotocin Induced Diabetic Rat Model

Introduction Type 1 diabetes is an autoimmune disorder that affects nearly 347 million people worldwide. The autoimmune disorder is characterized by the destruction of insulin-producing beta cells in the pancreas by the patient’s immune system. Because insulin...

Non – Surgical Model of Sepsis & Inflammation
Non – Surgical Model of Sepsis & Inflammation

Introduction The immune system is extraordinarily effective at eliminating small, local infections. However, when infection occurs systemically, such as in bacterial septicemia, a cascade of events is initiated in which potent mediators released by the immune system...

Neutropenic Mouse Thigh Model of Infection
Neutropenic Mouse Thigh Model of Infection

Introduction Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test...

Cotton Rat Model of RSV Infection
Cotton Rat Model of RSV Infection

Introduction Noble Life Sciences, in partnership with IBT Bioservices, has optimized a cotton rat RSV model and successfully demonstrated its use to test the efficacy of a therapeutic agent against RSV. RSV is a major human pathogen causing mild to severe respiratory...

Cotton Rat Model of Influenza Infection
Cotton Rat Model of Influenza Infection

Introduction Noble Life Sciences, in partnership with IBT Bio s services, has optimized a cotton rat model of influenza virus infection. Although vaccines and antiviral agents are effective in the prophylaxis and treatment of the disease, each year changes in the...

Mouse Peritonitis/Sepsis Model of MRSA Infection
Mouse Peritonitis/Sepsis Model of MRSA Infection

Noble Life Sciences, in collaboration with ImQuest Biosciences, has optimized the peritonitis/sepsis mouse model to screen for new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). The model’s popularity derives from its ease of use with small and expensive animals, short-duration experiments with reproducible infections, and simple end-points.

Biodistribution Studies for Cell and Gene Therapy Products
Biodistribution Studies for Cell and Gene Therapy Products

Figure 1. Overview of the biodistribution study of cell/gene therapy (CGT) product. The CGT product is injected into mice; tissue samples are harvested and DNA is isolated from all samples. DNA is then quantified and used as a template in quantitative polymerase chain...