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Sepsis Model Technical Note

The immune system is extraordinarily effective at eliminating small, local infections. However, when infection occurs systemically, such as in bacterial septicemia, a cascade of events is initiated in which potent mediators released by the immune system can endanger host survival. This whole body inflammatory state is referred to as sepsis. Sepsis can also occur in the absence of invading bacteria (“sterile sepsis”), for example, in cases of traumatic injury.

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