Resources
INDICATION
Navigating the Complexities of GLP Toxicology Studies for Biotech Companies
If you’ve worked in drug development, whether it be at a biotech or pharma company, you know just how critical Good Laboratory Practice (GLP) toxicology studies are in the preclinical process. These studies help evaluate the safety and potential risks associated with...
6 Things You Must Consider When Designing a Successful Preclinical Study in Oncology
Preclinical studies are essential for advancing oncology drug development programs. They provide valuable insights into a drug candidate's safety and efficacy before it moves into clinical trials. A well-designed preclinical study can increase the likelihood of...
Noble Life Sciences Receives Renewed Accreditation from AAALAC International for Continued Commitment to Ethical Animal Research
Sykesville, Maryland - June 20, 2023 Noble Life Sciences, a leading contract research organization in Maryland, is proud to announce that it has received renewed accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)...
Establishment of Human CD34+ Hematopoietic Stem Cell-Engrafted NOD SCID Gamma (NSG) Mice as a Humanized Immune System Mouse Model
Introduction Humanized mice are exceptional models for preclinical testing of cell and gene therapies. Standard mouse models can provide an approximation of human systems, but the murine immune system has important differences from humans. To overcome these...
Colon Cancer PDX Model: Platform for Preclinical Drug Screening
Introduction A patient-derived colon cancer Xenograft (PDX) model has been established for the first time by Noble Life Sciences by implanting cryopreserved PDX fragments into a transplant compliant mouse host. PDX models have advantages over cancer cell line...
In Vitro Tumor Cell Model Systems for Anticancer Drug Screening and Verification
Introduction With the increasing incidence of patients worldwide diagnosed with cancer, the development of effective, safe, and economically viable anticancer therapeutics remains a high priority. Early anticancer drug discovery and development is very challenging...
Toxicology Study Design Considerations
Safety pharmacology and toxicology studies are performed to understand the onset, degree of severity, and time length up to which a particular dose of a new drug demonstrates any toxic effects. The dosing regimens for such studies usually range from acute studies...
Preclinical Toxicology Considerations for a Successful IND Application
- Preclinical toxicology is a critical component of the drug development process. The goal of toxicology testing is to support the transition of a new drug candidate to patients in Phase I clinical studies through an investigational new drug (IND) filing. The IND...
New Digital PCR Service Now Available
Noble Life Sciences now offers Digital PCR services and expands Molecular Biology Facility’s capability for cell and gene therapy applications. Our digital PCR services utilizes the Qiagen QIAcuity four-plate digital PCR (dPCR) instrument that detects up to 5...
Navigating the Journey to Developing Successful Rare Disease Cell and Gene Therapies
Cell and gene therapies have the potential to change the way rare diseases are treated, offering novel and more effective treatments for patients with limited options. This article explores the various options available from the government to help rare disease drug...
GLP Custom Polyclonal Antibodies
For over 30 years, Noble Life Sciences has supplied custom polyclonal antibody services using a variety of animal species. Our GLP custom polyclonal antibodies are ideal for vaccine potency testing. We offer two standard protocols which are designed to maximize...
Medical Device Testing Services
Noble Life Sciences offers a wide range of testing GLP services to ensure both the efficacy and safety of medical devices with significant expertise in orthopaedic, cardiovascular, trauma, and wound models. We provide surgical expertise and support utilizing state of...
Choosing the Right Preclinical Development Partner for Grant Programs
Small businesses in the United States are afforded the opportunity to develop technological or scientific innovations through grant programs such as the SBIR, STTR, DOD, and NSF. These highly competitive programs are one of the largest sources of capital for funding...
TCGA Publishes Highly Anticipated Results on Tumor Sequencing
The Cancer Genome Atlas (TCGA)—a comprehensive and coordinated effort to accelerate understanding of the molecular basis of cancer through the application of genome analysis technologies, supported by the National Cancer Institute and National Human Genome Research...
Evaluating Agents for the Treatment of Sepsis Using Infectious Disease Models
Sepsis is one of the 10 leading causes of death worldwide. According to the Centers for Disease Control, more than 1.5 million people in the United States contract sepsis yearly, and around 250,000 of these people die from its associated complications. In 2015, sepsis...
Preclinical Models in CAR T-cell Therapy: Promising new approach to study tumor clearance by CAR T-cells
The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison of the United States and Tasuku Honjo of Japan for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has herald in an entirely new class of treatment...
Antibiotic Resistance – Challenges and New Opportunities
The misuse of existing antibiotics in clinical practice and the introduction of antibiotics into the environment in combination with the inherent adaptive nature of microorganisms has led to a major global health crisis with the evolution of antibiotic-resistant...
Orthotopic Liver Cancer Model Established in Athymic Nude Mice
Introduction The study aims to establish an orthotopic liver cancer model in nude mice and evaluate the anti-tumor efficacy of Sorafenib. Liver cancer is a leading cause of cancer deaths worldwide, accounting for approximately 830,000 deaths each year. Hepatocellular...
Vaccine, Drug, Medical Device | Custom Polyclonal Antibodies | Vivarium Services
Noble Life Sciences Now Offers Live Animal Imaging for Preclinical Stu PerkinElmer IVIS Lumina LT III Gain simultaneous insights into the efficacy, kinetics, target, and mechanism of action of your drug candidate non-invasively. The IVIS is particularly suited for...
Structural and Functional Equivalency Between Lyopreserved and Cryopreserved Chorions with Viable Cells
Vimal Jacob, Nicholas Johnson, Anne Lerch, Brielle Jones, Sandeep Dhall,* Malathi Sathyamoorthy,* and Alla Danilkovitch Research and Development, Osiris Therapeutics, Inc., Columbia, Maryland. These authors contributed equally to this study.Objective: Clinical studies...
Viable Cryopreserved Umbilical Tissue (vCUT) Reduces Post-operative Adhesions in a Rabbit Abdominal Adhesion Model
Sandeep Dhalla, Turhan Coksayganb, Tyler Hoffmana, Matthew Moormana, Anne Lercha, Jin-Qiang Kuanga, Malathi Sathyamoorthya, Alla Danilkovitcha, Osiris Therapeutics, Inc., 7015 Albert Einstein Dr, Columbia, MD, 21046, USA, and University of Maryland, 655 W. Baltimore...
Anti-Infectious Therapeutic Development Services
WHY NOBLE LIFE SCIENCES? • Dedicated Study Director for each project• Highly Skilled Technical Team• Qualified animal Care Team• Interactive Study Design and ExecutionNoble’s highly experienced scientist have been implementing effective and efficient approaches to...
Oncology Drug Testing
WHY NOBLE LIFE SCIENCES? Dedicated Study Director for each project Highly Skilled Technical Team Qualified animal Care Team Interactive Study Design and Execution Noble’s highly experienced scientist have been implementing effective and efficient approaches to help...
GLP Toxicology Services
Toxicology studies are required to determine the adverse effects of drug candidates and the effect of dosage on toxicity. With extensive experience in vaccine and drug development, Noble Life Sciences’ staff is dedicated to helping you complete your project in a...
Rabbit Abdominal Sidewall Adhesion Model
Service Description The rabbit abdominal sidewall adhesion model is a reproducible and effective model to study adhesion formation and evaluate materials to prevent adhesions. Moreover, the model is flexible, e.g., laparoscopic procedures can be employed and various...
Continuous Drug Infusion Model with an Implantable Osmotic Pump
Introduction Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery. The...
Clinical Aspects of Acute and Chronic Wound Healing: Swine As Preclinical Model For Developing Therapies For Skin Wound Healing
Introduction Skin serves as a barrier between the external environment and the underlying tissues. When the integrity of the skin is disrupted this barrier is compromised. In order to prevent further damage or infection, proper wound healing should occur immediately....
Streptozotocin Induced Diabetic Rat Model
Introduction Type 1 diabetes is an autoimmune disorder that affects nearly 347 million people worldwide. The autoimmune disorder is characterized by the destruction of insulin-producing beta cells in the pancreas by the patient’s immune system. Because insulin...
Non – Surgical Model of Sepsis & Inflammation
Introduction The immune system is extraordinarily effective at eliminating small, local infections. However, when infection occurs systemically, such as in bacterial septicemia, a cascade of events is initiated in which potent mediators released by the immune system...
Neutropenic Mouse Thigh Model of Infection
Introduction Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test...
Cotton Rat Model of RSV Infection
Introduction Noble Life Sciences, in partnership with IBT Bioservices, has optimized a cotton rat RSV model and successfully demonstrated its use to test the efficacy of a therapeutic agent against RSV. RSV is a major human pathogen causing mild to severe respiratory...
Cotton Rat Model of Influenza Infection
Introduction Noble Life Sciences, in partnership with IBT Bio s services, has optimized a cotton rat model of influenza virus infection. Although vaccines and antiviral agents are effective in the prophylaxis and treatment of the disease, each year changes in the...
Mouse Peritonitis/Sepsis Model of MRSA Infection
Noble Life Sciences, in collaboration with ImQuest Biosciences, has optimized the peritonitis/sepsis mouse model to screen for new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). The model’s popularity derives from its ease of use with small and expensive animals, short-duration experiments with reproducible infections, and simple end-points.
Animal Models for the Development of Vaccines and Therapeutics for Influenza Infections
The mouse and ferret animal models are the most widely used models for influenza studies. Each has its advantages. The mouse model provides a relatively low-cost system with a variety of genetic backgrounds and an arsenal of commercially available immunologic reagents...
Immunophenotyping of Tumor-Infiltrating Immune Cells in Mouse Syngeneic Tumor Models Using Multi-Color Flow Cytometry Assays
The in vivo animal tumor models possessing fully functional immunity are essential for preclinical research of new immunotherapeutic medicine. Syngeneic tumor models are powerful in vivo animal models that meet the need in preclinical research for testing innovative...
Biodistribution Studies for Cell and Gene Therapy Products
Figure 1. Overview of the biodistribution study of cell/gene therapy (CGT) product. The CGT product is injected into mice; tissue samples are harvested and DNA is isolated from all samples. DNA is then quantified and used as a template in quantitative polymerase chain...
Noble Life Sciences announces its collaboration with George Mason University to access the National Center for Biodefense and Infectious Diseases BSL-3 facility
Sykesville, MD, and Fairfax, VA, December 21, 2020 – Noble Life Sciences (NLS), a preclinical contract research organization located in Sykesville, MD, has signed a Collaboration Agreement with George Mason University (Mason) to access the National Center for...
Noble Life Sciences is Granted Renewal of Full Accreditation from AAALAC
Sykesville, MD, March 13, 2020 - Noble Life Sciences is excited to announce renewal of full accreditation from Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International Council. Noble Life Sciences has held full AAALAC accreditation...