Animal Models of Disease
There is an increasing demand for the development of novel effective anti-microbial therapeutics. This demand is driven by both the appearance of novel infectious disease agents and the global emergence of life-threatening multidrug-resistant infectious agents arising primarily due to the overuse of antibiotics. Noble’s expertise in animal models can be leveraged to study the efficacy of candidate drugs, explore drug toxicity and validate biomarkers.
Noble Life Sciences provides a panel of optimized animal models to screen new antiviral and antibacterial agents against infectious and resistant pathogens. The use of these models is based on their effectiveness and acceptability within the scientific literature for the development of anti-infectious drugs. End-points can include in vivo physiological measurements, and/or quantification of the infectious agent within the treated animal, and may be coupled with PK/PD analysis.
Noble Life Sciences can also work with clients as a dedicated arm of your drug discovery team to develop and implement new animal models of infection for the development of novel anti-infectious agents.
Our extensive range of models includes:
Virology
- RSV: Cotton Rat models
- Influenza: Ferret, Mouse, and Cotton Rat Models
Bacteriology
- Diabetes Wound Infection Models
- Bacterial infection models including Neutropenic Thigh Model, Sepsis and Lung Infection Model
Surgical Site Infection models
Immunogenicity models for vaccine development
Models
- Cotton Rat Influenza Model
- Cotton Rat Influenza Model Technical Note
- Cotton Rat RSV Model
- Cotton Rat RSV Model Technical Note
- Neutropenic Thigh Model
- Neutropenic Thigh Model Technical Note
- Non-Surgical Sepsis Model
- Sepsis Model Technical Note
- MRSA Peritonitis-Sepsis Model
- MRSA Sepsis Model Technical Note
Model Optimization
You have direct access to Noble scientists who will optimize your animal disease model to fit the unique needs of your development program.
Our specialists have experience with a variety of drug administration options:
Our specialists have experience with a variety of drug administration options:
- Oral Gavage
- Continuous Infusion
- Continuous Infusion Technical Note
- Dietary Admixture
- Dermal
- Intravenous
- Subcutaneous
- Intradermal
- Intramuscular
- Intraperitoneal
- Intranasal
Imaging capabilities
Live animal imaging with the Perkin Elmer IVIS system using bioluminescent or fluorescent reporters
Infectious Disease Capabilities
Animal Models
Viral Infection Models
- Influenza: Mice, Ferrets, Cotton Rat
- RSV: Mice, Cotton Rat
- SARS-CoV2: Mice
Bacterial Infection Models
- Neutropenic Thigh Infection: Mice, Rats, Guinea Pigs
- Lung Infection Model: Mice
- Bacteremia/Sepsis Model: Mice, Rats
- Surgical Site Infection
- Wound Infection
- Biofilm
Assays
- Protein/Cytokine Analysis
- Viral Quantificaiton
- Bacterial Characterization/Quantification
- Cellular responses
BSL-3 Laboratories—SARS-CoV-2 testing
Biomedical Research Laboratory – George Mason University, Manassas, VA
SARS-CoV-2 strains
- Alpha
- Beta
- Gamma
- Delta
- Kappa
- Iota
- Lambda
- Omicron
Assays available
- PRNT
- ELISA
- RT-qPCR
- Plaque assay
- TCID50
SARS-CoV-2 Mouse Model
Features
- Transgenic mice expressing the human ACE2 receptor
- Lethal challenge model
Advantages
- Small animal
- Availability of commercial
immunological reagents and
assays to characterize response
Preclinical Vaccine Development Services
Protocol Development
- Experienced in conventional and nucleic acid vaccines
- Adjuvant testing and selection
In vivo Options
- Rodents
- Guinea Pigs
- Rabbits
- Ferrets
- Large animals
Challenge-protection Studies
- Clinical observations
- In vitro determinations
Toxicology Studies
- Single-dose and repeat-dose
- Acute, sub-chronic, and chronic
- Biodistribution
Immunogenicity Testing
- Immunization and boost
- Pre- and post-injection sample collection
- Serology
Related Services
- Immunoassays
- Viral & bacterial neutralization
- Vaccine stability testing
- Custom antibody production
Noble Talent
Meet our Director of Preclinical Research of Infectious Diseases
Todd has more than 25 years of experience in academia and the private sector with extensive expertise in molecular biology and microbiology.
Todd Parsley, Ph.D.
Director, Infectious Diseases
We can help to fight against Infectious Diseases
Resources & White Papers
PASSIONATE ABOUT COLLABORATING FOR A CURE
Orthotopic Liver Cancer Model Established in Athymic Nude Mice
Introduction The study aims to establish an orthotopic liver cancer model in nude mice and evaluate the anti-tumor efficacy of Sorafenib. Liver cancer is a leading cause of...
Mouse Peritonitis/Sepsis Model of MRSA Infection
Noble Life Sciences, in collaboration with ImQuest Biosciences, has optimized the peritonitis/sepsis mouse model to screen for new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). The model’s popularity derives from its ease of use with small and expensive animals, short-duration experiments with reproducible infections, and simple end-points.
Animal Models for the Development of Vaccines and Therapeutics for Influenza Infections
The mouse and ferret animal models are the most widely used models for influenza studies. Each has...
Immunophenotyping of Tumor-Infiltrating Immune Cells in Mouse Syngeneic Tumor Models Using Multi-Color Flow Cytometry Assays
The in vivo animal tumor models possessing fully functional immunity are essential for preclinical research of new immunotherapeutic medicine. Syngeneic tumor models are...