Optimize Your Therapeutics

Infectious Diseases

Noble’s experience with animal models makes us the perfect partner to help study the effectiveness of new drugs, test for toxicity, and validate biomarkers. Benefit from our qualified scientists who are proficient with a variety of drug administration options.

  • Antiviral
  • Antibacterial
  • Vaccines
  • BSL-2 and BSL-3 agents
Let Noble Life Sciences’ unparalleled expertise and state-of-the-art facilities be your trusted partner for all of your preclinical biodistribution and shedding studies. We have worked with xx organizations to bring xx new therapies to market.

Animal Models of Disease

There is an increasing demand for the development of novel effective anti-microbial therapeutics. This demand is driven by both the appearance of novel infectious disease agents and the global emergence of life-threatening multidrug-resistant infectious agents arising primarily due to the overuse of antibiotics. Noble’s expertise in animal models can be leveraged to study the efficacy of candidate drugs, explore drug toxicity and validate biomarkers.

Noble Life Sciences provides a panel of optimized animal models to screen new antiviral and antibacterial agents against infectious and resistant pathogens. The use of these models is based on their effectiveness and acceptability within the scientific literature for the development of anti-infectious drugs. End-points can include in vivo physiological measurements, and/or quantification of the infectious agent within the treated animal, and may be coupled with PK/PD analysis.

Noble Life Sciences can also work with clients as a dedicated arm of your drug discovery team to develop and implement new animal models of infection for the development of novel anti-infectious agents.

Our extensive range of models includes:

Virology

  • RSV: Cotton Rat models
  • Influenza: Ferret, Mouse, and Cotton Rat Models

Bacteriology

  • Diabetes Wound Infection Models
  • Bacterial infection models including Neutropenic Thigh Model, Sepsis and Lung Infection Model

Surgical Site Infection models

Immunogenicity models for vaccine development

Models 

  • Cotton Rat Influenza Model
  • Cotton Rat Influenza Model Technical Note
  • Cotton Rat RSV Model
  • Cotton Rat RSV Model Technical Note
  • Neutropenic Thigh Model
  • Neutropenic Thigh Model Technical Note
  • Non-Surgical Sepsis Model
  • Sepsis Model Technical Note
  • MRSA Peritonitis-Sepsis Model
  • MRSA Sepsis Model Technical Note

Model Optimization

You have direct access to Noble scientists who will optimize your animal disease model to fit the unique needs of your development program.
Our specialists have experience with a variety of drug administration options:

Our specialists have experience with a variety of drug administration options:

  • Oral Gavage
  • Continuous Infusion
  • Continuous Infusion Technical Note
  • Dietary Admixture
  • Dermal
  • Intravenous
  • Subcutaneous
  • Intradermal
  • Intramuscular
  • Intraperitoneal
  • Intranasal

Imaging capabilities

Live animal imaging with the Perkin Elmer IVIS system using bioluminescent or fluorescent reporters

Infectious Disease Capabilities

Animal Models

Viral Infection Models

  • Influenza: Mice, Ferrets, Cotton Rat
  • RSV: Mice, Cotton Rat
  • SARS-CoV2: Mice

Bacterial Infection Models

  • Neutropenic Thigh Infection: Mice, Rats, Guinea Pigs
  • Lung Infection Model: Mice
  • Bacteremia/Sepsis Model: Mice, Rats
  • Surgical Site Infection
  • Wound Infection
  • Biofilm

Assays

  • Protein/Cytokine Analysis
  • Viral Quantificaiton
  • Bacterial Characterization/Quantification
  • Cellular responses

BSL-3 Laboratories—SARS-CoV-2 testing

Biomedical Research Laboratory – George Mason University, Manassas, VA

SARS-CoV-2 strains

  • Alpha
  • Beta
  • Gamma
  • Delta
  • Kappa
  • Iota
  • Lambda
  • Omicron

Assays available

  • PRNT
  • ELISA
  • RT-qPCR
  • Plaque assay
  • TCID50

SARS-CoV-2 Mouse Model

Features

  • Transgenic mice expressing the human ACE2 receptor
  • Lethal challenge model

Advantages

  • Small animal
  • Availability of commercial
    immunological reagents and
    assays to characterize response

Preclinical Vaccine Development Services

Protocol Development

  • Experienced in conventional and nucleic acid vaccines
  • Adjuvant testing and selection

In vivo Options

  • Rodents
  • Guinea Pigs
  • Rabbits
  • Ferrets
  • Large animals

Challenge-protection Studies

  • Clinical observations
  • In vitro determinations

Toxicology Studies

  • Single-dose and repeat-dose
  • Acute, sub-chronic, and chronic
  • Biodistribution

Immunogenicity Testing

  • Immunization and boost
  • Pre- and post-injection sample collection
  • Serology

Related Services

  • Immunoassays
  • Viral & bacterial neutralization
  • Vaccine stability testing
  • Custom antibody production

Noble Talent

Meet our Director of Preclinical Research of Infectious Diseases

Todd has more than 25 years of experience in academia and the private sector with extensive expertise in molecular biology and microbiology.

 

Todd Parsley, Ph.D.

Todd Parsley, Ph.D.

Director, Infectious Diseases

We can help to fight against Infectious Diseases

Resources & White Papers

PASSIONATE ABOUT COLLABORATING FOR A CURE