Let Noble Life Sciences’ unparalleled expertise and state-of-the-art facilities be your trusted partner for all of your preclinical biodistribution and shedding studies. We have worked with xx organizations to bring xx new therapies to market.

The Industry Standard

Noble’s OncoDiversity Cell Line Panel will hit the target

Noble will screen your drug candidates using our OncoDiversity Cell Line Panel, a diverse collection of cell lines spanning multiple cancer indications.

Results from the cell line panel screen can be matched to the genetic background in the cancer cell lines to determine a molecular biomarker profile correlating with the activity of your drug candidate.

Noble’s biobank resource containing DNA and protein from each cell line is then used to confirm the drug: biomarker correlations that were discovered in the cell panel screen.

Validation of the drug and biomarker response in vivo can be carried out in cell models shown to be sensitive to your drug.

These studies provide an understanding of the expression status of the target and molecular pathway in the selected model; determination of the active plasma concentrations of the drug; modulation of the downstream pathway in which the target functions; and assessment of the therapeutic index.

By examining the response of a broad spectrum of validated DNA and protein-based biomarkers to therapeutics, we deliver data that enables more confident decisions.

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Live animal imaging with the Perkin Elmer IVIS system using bioluminescent or fluorescent reporters

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Live animal imaging with the Perkin Elmer IVIS system using bioluminescent or fluorescent reporters

Oncology Drug Testing cover thumbnail

Oncology Drug Testing

Oncology Drug Testing cover thumbnail

Oncology Drug Testing

Scientific Advisor Team

Our oncology team is committed to fight The Fight

by advancing your preclinical research.

Stephen K. Horrigan, Ph.D.

Stephen K. Horrigan, Ph.D.

Chief Scientific Officer

Pang-Kuo Lo, Ph.D. MSc

Pang-Kuo Lo, Ph.D. MSc

Team Lead, Assay Development

Arundhati Ghosh, Ph.D., MSc

Arundhati Ghosh, Ph.D., MSc

Study Director

Yongping Chen, M.D., Ph.D.

Yongping Chen, M.D., Ph.D.

Senior Study Director

We can help to lead the global fight against cancer

Resources & White Papers

PASSIONATE ABOUT COLLABORATING FOR A CURE

Mouse Peritonitis/Sepsis Model of MRSA Infection

Mouse Peritonitis/Sepsis Model of MRSA Infection

Noble Life Sciences, in collaboration with ImQuest Biosciences, has optimized the peritonitis/sepsis mouse model to screen for new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). The model’s popularity derives from its ease of use with small and expensive animals, short-duration experiments with reproducible infections, and simple end-points.

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