We improve research and reduce risks at all stages of development.
Cell and Gene Therapy
As a trailblazer in the industry, Noble helps you navigate the challenges unique to cell and gene therapies. Our experienced team is ready to guide you through the continuously evolving high-standards, challenges, and changes you’ll face in the cell and gene therapy industry.
We improve research and reduce risks at all stages of development.
Cell and Gene Therapy
As a trailblazer in the industry, Noble helps you navigate the challenges unique to cell and gene therapies. Our experienced team of experts is ready to guide you to face high-standards challenges and the continuous evolution of the clinical and regulatory industry.
Cell and Gene Therapy
We improve research and reduce risks at all stages of development.
As a trailblazer in the industry, Noble helps you navigate the challenges unique to cell and gene therapies. Our experienced team is ready to guide you through the continuously evolving high-standards, challenges, and changes you’ll face in the cell and gene therapy industry.
Biodistribution & Shedding
Biodistribution & Shedding
Toxicology
Toxicology
Efficacy
Efficacy
Immunoassays
Immunoassays
Management of complexity and processes for the long assay development time.
Flow Cytometry
Flow Cytometry
Proof-of-Concept Studies
Cell and Gene Therapy CRO Services
Our team of experts will help develop assays to ease the research path, obtain FDA authorizations, and understand the importance of clinical strategy, protocol design, and feasibility.
From protocol design to data management, our best practices in managing therapies will guide you to develop the Proof-of-concept of your cell and gene therapy product.
Cell & Gene Therapeutic Research
3 Strategies to Use When Selecting a CRO For a Gene Therapy Study
- Do your due diligence when researching each CRO for your cell-gene therapy study
- Look for robust assay and model development experience
- Anticipate the challenges associated with cell-gene therapy studies
Cell and Gene Therapy IND Enabling Studies
Generate IND ready data for your FDA submission
Quality and Regulatory support
Hybrid pharmacology/ toxicity/ activity studies
- Pharmacodynamic marker analysis
- Local and systemic toxicity
- Histopathology
Inflammatory/immune response
- Blood cytokine analysis
- Immune system cellular response
Cell product characterization
- Insertion site analysis
- Transgene characterization
Biodistribution location and persistence of the product
- Real time PCR
- Flow Cytometry
- Animal imaging
DEXA Imaging Capabilities: Body & Bone Metrics
Our DEXA Scanning Capabilities Support a Range of Preclinical Applications:
- Non-Invasive Precision: Accurately measure bone density and body composition in live animals for metabolic, musculoskeletal, and aging studies.
- Whole-Body Composition: Quantify lean mass, fat mass, and bone density to support safety and efficacy endpoints.
- Longitudinal Monitoring: Track treatment effects over time without sacrificing animals, reducing variability and improving data quality.
- Regulatory-Ready Data: Generate reproducible, quantitative results suitable for IND-enabling submissions.
- Seamless Integration: Easily incorporated into pharmacology, toxicology, and efficacy studies for a comprehensive in vivo profile.
Cell & Gene Therapy
Access unparalleled scientific, operational, and regulatory solutions across the entire cell and gene therapy development continuum—right from the start.
Resources & White Papers
PASSIONATE ABOUT COLLABORATING FOR A CURE
DSS-Induced Colitis Mouse Models
Inflammatory bowel disease (IBD) is a chronic, remitting, and relapsing inflammatory disorder encompassing Crohn’s disease (CD) and ulcerative colitis (UC). CD is predominantly...
Orthotopic Liver Cancer Model Established in Athymic Nude Mice
Introduction The study aims to establish an orthotopic liver cancer model in nude mice and evaluate the anti-tumor...
Mouse Peritonitis/Sepsis Model of MRSA Infection
Noble Life Sciences, in collaboration with ImQuest Biosciences, has optimized the peritonitis/sepsis mouse model to screen for new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). The model’s popularity derives from its ease of use with small and expensive animals, short-duration experiments with reproducible infections, and simple end-points.
Animal Models for the Development of Vaccines and Therapeutics for Influenza Infections
The mouse and ferret animal models are the most widely used models for influenza studies. Each has its advantages. The mouse model provides a relatively low-cost system with a...